The Lillemeier laboratory studies the spatio-temporal organization of the plasma membrane and its impact on signal transduction. We are specifically interested in T cell antigen recognition, activation and signaling. We are also investigating other aspects of membrane biology, e.g. virus-host interactions, anthrax toxin uptake and membrane aging. To achieve this, our research team uses cutting edge fluorescence microscopy techniques, e.g. super-resolution microscopy and cross-correlation spectroscopy. Another focus in the laboratory is to study the qualitative and quantitative differences of signal transduction that determine T cell fate and function. To this end, we use innovative biochemical and molecular biological approaches.